MitoBurn™ (L-β-Aminoisobutyric Acid) Explained
The Gains Candy series gets MitoBurn added to the mix and this is one powerful ingredient!
Get your notebooks ready, because in order to truly appreciate and understand what MitoBurn™ is capable of, we’re going to have to explain some physiological mechanisms behind how it works.
What Even is BAIBA Anyways?
At this point you’re probably on the edge of your seat, trying to figure out what BAIBA even is, so let us explain… because although it seems like “magic”, it’s actually something your body generates when you exercise, but there’s an abundance of research that help reveals its tricks and demonstrate how supplementing more could help even more!
First of all, BAIBA is a non-protein amino acid and stands for β-Aminoisobutyric Acid. It’s technically classified as a myokine, “myo” means muscle, and “kine” represents signaling. This means BAIBA gets released from skeletal muscle during exercise, and through cell signalling, creates a cascade of positive effects that include increased fat burning (beta-oxidation), brown fat activation, and thermogenesis. However, there’s a little more you need to know in order to reap all the benefits BAIBA has to offer, and it all starts with the letter L.
The Tale of Two BAIBAs: L-BAIBA and D/R-BAIBA
As you can see from the label on Gains Candy, there’s an “L” in front of it. This may seem like a minuscule detail, but it can’t be overlooked.
Thymine vs Valine
There are actually two forms, also called enantiomers, of BAIBA that exist: the almighty exercise-induced L-BAIBA, and its mirrored cousin, D/R-BAIBA. They are both endogenously produced, but the substrates in which they are derived from are different. L-BAIBA comes from the metabolism of an essential amino acid valine. D/R-BAIBA is created from the breakdown of thymine, a nucleic acid that’s a constituent of DNA and RNA synthesis.
L-BAIBA takes the crown because research shows its metabolic health benefits far outweigh the other form. D/R-BAIBA may possess some positive effects, but with how much more biologically active L-BAIBA is, it doesn’t even come close. Research shows that L-BAIBA is the main form that’s secreted from working skeletal muscle, and has earned the title of “exercise-induced muscle factor”.
Pure L-BAIBA, the metabolite of Valine that jumpstarts the exercise “metabolic program”
The above makes complete sense when you refer back to where it comes from, valine, an essential branched-chain amino acid in various foods and popular supplements like Alpha Lion’s GAIN-O-RADE. Valine was known for its role in muscle protein and glycogen synthesis, but now with the discovery of L-BAIBA, we realize there’s something else more powerful that it has to offer. The workout amino breaks down into the workout exercise signal.
In summary, when you exercise, there’s a pretty large increase in amino acid oxidation, and valine breaks down into L-BAIBA, which signals to the rest of your body that there’s some metabolic work to be done!
Exercise in a Pill?
Naturally, exercise scientists started to wonder if exogenous supplementation with L-BAIBA could result in the same effects seen with exercise: increased thermogenesis, improved insulin sensitivity, better lipid profiles, and glucose control. Well, that’s just what they found in animal models, but could there really be something that could be considered “exercise in a pill”? Likely not, but L-BAIBA may be the closest thing yet.
NNB Nutrition has finally brought us a trusted and tested form of L-BAIBA, which we call an “exercise signal” that kickstarts incredible metabolic processes!
MitoBurn is a very novel ingredient, but the preliminary studies on L-BAIBA look very promising! For a disclaimer, many of the studies we will discuss have been done in animals. Many people immediately dismiss animal research, however it’s crucial in the advancement of science, and even at “heroic” doses, no LD50 could be discovered on the animals yet. With that said, let’s see what the research has to say!
The Literature On BAIBA
Research conducted in animal models have found that BAIBA supplementation can lead to:
Increased Fatty Acid Oxidation
BAIBA has been shown to help increase liver fatty acid oxidation within the mitochondria. When it comes to preventing several cardiometabolic diseases, this is critical, because fat that surrounds the organs (visceral fat) is much more detrimental to health that subcutaneous fat.
What’s interesting is that someone could look relatively lean and in shape, but if a body scan reveals that they have an excessive amount of visceral fat, then they are at a higher risk of several health conditions. This is known as “TOFI”, or thin on the outside, fat on the inside – and it’s dangerous because people do not realize they’re sick until way later, whereas an overweight or obese person knows they’re eventually headed for trouble and have time to correct course.
Thus finding something that can tap into those stubborn fat stores is very beneficial, going beyond appearance. It would make sense for the body to use subcutaneous fat opposed to visceral, based on survival mechanisms. Remember, obesity is protective in ways. But long-term, too much of either type of fat storage eventually leads to harm.
Greater Conversion of White Adipose Tissue to Brown/Beige Adipose Tissue
A study done in 2014 showed BAIBA was able to stimulate the thermogenic programming within white adipose tissue (WAT), meaning it made them more metabolically active. This is ideal for anyone trying to lose weight and keep it off for good!
“BAIBA is released from the muscle after an exercise bout, promoting differentiation of brown adipocyte-like cells within subcutaneous fat depots and fat oxidation in the liver.”
White adipocytes are considered to be our fat storage, so they don’t really do much in terms of generating energy for us to use during exercise. Brown adipocytes on the other hand, are much easier for the body to tap into and create more energy. It actually generates heat via mitochondrial uncoupling, resulting in more thermogenesis. BAIBA is able to help convert more WAT to brown (or beige, really) by activating a pathway known as P-PAR alpha.
As we discussed, BAIBA is a myokine, and it signals to various molecules within the body to carry out its effects. In summary, more brown adipose tissue will mean greater fat oxidation (fat burning) which is exactly what you’re after!
Enhanced Ketone Body Production
Along the same lines of the study we just discussed above, this one discovered that supplementation of BAIBA resulted in increased ketone body production, specifically beta-hydroxybutyrate(BHB).
BHB is considered to be the main ketone body synthesis during fatty acid oxidation, therefore it’s a key indicator of great fat burning. The primary ketone body generated when beta-oxidizing fat. Furthermore, BAIBA consumption also significantly enhances another prevalent ketone body acetoacetate. It’s fairly safe to say BAIBA may be classified as a ketogenic compound and this studies’ findings are further reinforced by the 2004 study, showing increased hepatic fatty acid oxidation.[6,7]
Prevention of Lipogenesis In A State of Partial Leptin Deficiency
Do you ever get that raging feeling of hunger? Well you can probably blame it on low levels of leptin, because it’s the hormone responsible for being satiated and feeling full. Leptin is mainly secreted by fat cells, so if you meet people who are incredibly lean and never feel full, it’s because they don’t have a lot of fat to secrete leptin. So the body is signaling that it needs more energy for survival.
Leptin Feedback Loop
Getting caught in the “Leptin Negative Feedback Loop” is one of the biggest challenges you can create for yourself. Can BAIBA supplementation help anyone break the cycle?
But this same effect can also happen in obese people, where they become less sensitive to leptin and as a result, never feel satiated.
And what ends up happening is that they eat more food! However, in opposition to the extremely lean person, if you’re overweight, the last thing you need is more incoming energy, so your body is getting mixed signals. Do I lose fat or keep it because I’m “starving”? This is one of the many reasons fat loss can be extremely difficult for some people.
Although further research is needed, one study’s findings suggest BAIBA may be the solution to this problem. It found that BAIBA was able to almost completely prevent weight gain in mice that were partially deficient in leptin. Furthermore, it also found increased liver fatty acid oxidation! It’s always great to see when multiple studies are finding similar things, that just strengthens the consensus even more.
Improved Insulin Sensitivity and Blood Glucose Handling
One of the biggest issues people face with having too much body fat is being insulin resistant, or lacking the ability to properly control blood glucose levels. If it gets worse enough, you could even develop diabetes. This makes it extremely difficult to lose weight and can develop into serious medical conditions.
Exercising regularly and eating a more well-balanced diet are two of the easiest and most effective ways you can prevent insulin resistance from happening, but to see even greater results, definitely consider using BAIBA. One study found that after only four weeks of oral BAIBA supplementation, there was a positive effect on multiple enzymes associated with insulin resistance and fat accumulation in diabetic mice.
Waist Circumference Insulin Resistance
You can consider insulin resistance to mean “sugar saturation” – at some point, overfilled adipocytes refuse to store more energy. Image courtesy Dr. Ted Naiman.
In addition to that, the researchers noticed a significant reduction in blood glucose and lipid levels. It’s also interesting to note that during the study, they gave the mice a large bolus of glucose, and the ones taking BAIBA had little to no problems keeping their blood glucose in check. And this was even with an increased amount of calories! Obviously BAIBA is not an excuse to go pound a bag of doughnuts, it’s just meant to help you reach your goals faster along with a healthy eating and training regimen.
One more thing to note for this section is that a different study concluded that BAIBA is also effective at increasing glucose tolerance even on a more high-fat, low-carb diet, which can be constructed to become diabetic for mice. They overfed mice with a large amount of fat until they were insulin resistant. The mice that received BAIBA had less weight gain and better blood glucose control.
Reduced Risk Of Bone and Muscle Loss
The skeletal system is in very close proximity to the muscular system, and since BAIBA gets secreted from the skeletal muscle during exercise, it makes sense that it would also have an effect on bone.
As you get older, doing weight bearing activities becomes crucial for bone health and longevity. Unfortunately, osteoporosis (bone loss) and sarcopenia (muscle loss) are two conditions that go hand in hand with aging.[12.13] Even though they are almost inevitable, by exercising and eating right, you can delay them as long as possible.
BAIBA Bone Protection
New research has shown that BAIBA may protect from disuse-based bone loss thanks to it preventing osteocyte cell death that would have been induced by reactive oxygen species (ROS).[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832359/]
Yet again, researchers are looking into the effects of BAIBA on bone and muscle loss to see if it can at least help prevent it as much as possible. In order to see if it has any positive effects, they took some mice and unloaded their hind legs.This will cause atrophy and loss of bone mass rather quickly because they are not weight bearing at all. If you’ve ever had an injury that needed to be casted or immobilized for several weeks, you know how fast you lose muscle.
The study found that BAIBA yet again came to the rescue by preventing reactive oxygen species from breaking down mitochondria, which resulted in less overall cell death! It’s not that BAIBA will stop all muscle or bone loss, but it may help you recover faster because you’ll be starting in a better spot then without it.
Protection Against Renal Fibrosis
Renal fibrosis is caused by kidney disease, and since BAIBA has been shown to have a protective effect against other health conditions, the researchers hypothesized that it may help with this condition as well. The animal-based results showed that BAIBA slowed the disease progression inhibiting fibroblasts, which are cells that are creating the excess connective tissue. This is a very interesting finding and we can’t wait to see other studies that come out soon!
Serving Size: 1 capsule
MitoBurn™ (L-B-Aminoisobutyric Acid) 250mg
Other Ingredients: Rice Flour, Silica, Magnesium Stearate, Titanium Dioxide, FD&C Blue #1, FD&C Red #3, FD&C Yellow #6, FD&C Red #40, FD&C Yellow #5, FD&C Yellow #5, FD&C Green #3.
|Take 1 capsule once when you wake up and once before exercise.|
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